88 articles - From Saturday Feb 26 2022 to Friday Mar 04 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Aliment Pharmacol Ther |
meta-analyses and systematic reviews
| Inflamm Bowel Dis |
The Relationship Between Opioid Use and Healthcare Utilization in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Opioids use among patients with IBD is associated with increased healthcare utilization. Nonopioid alternatives are needed to reduce burden on the healthcare system and improve patient outcomes. |
| Neurogastroenterol Motil |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Adherence to endoscopic surveillance for advanced lesions and colorectal cancer in inflammatory bowel disease: an AEG and GETECCU collaborative cohort study. Adherence to endoscopic surveillance allows earlier detection of advanced lesions but is low. Groups at higher risk of CRC are associated with lower adherence. |
Comparative efficacy of an optimal exam between ultrasound versus abbreviated MRI for HCC screening in NAFLD cirrhosis: A prospective study. More than one-third of participants with NAFLD cirrhosis had severe visualisation limitations on US for HCC screening, compared with one-sixth on AMRI. US adequacy should be reported in al clinical studies and when suboptimal then AMRI may be considered for HCC screening. |
Early improvement in bowel wall thickness on transperineal ultrasonography predicts treatment success in active ulcerative colitis. Improvement in rectal bowel wall thickness measured using transperineal ultrasonography at week 1 predicts treatment success and potentially facilitates decision making during the early course of induction therapy in UC. |
Model to predict on-treatment restoration of functional HBV-specific CD8+ cell response foresees off-treatment HBV control in eAg-negative chronic hepatitis B. Short-term low-level antigen exposure and early long-term NUC treatment influence the restoration of a functional HBV-specific CD8 + cell response. Based on these predictors, a high likelihood of detecting this response at treatment withdrawal is associated with off-treatment HBV control and HBsAg decline and loss. |
Sofosbuvir and risk of estimated glomerular filtration rate decline or end-stage renal disease in patients with renal impairment. Clinical trial participants with CKD did not experience worsening eGFR during sofosbuvir-based treatment, and sofosbuvir was not associated with an increased risk of ESRD in patients with CKD in a nationally-representative administrative claims database. |
Stringent screening strategy significantly reduces reactivation rates of tuberculosis in patients with inflammatory bowel disease on anti-TNF therapy in tuberculosis endemic region. The high risk of TB reactivation with anti-TNF therapy in TB endemic regions can be significantly mitigated with stringent LTB screening and chemoprophylaxis. |
Subcutaneous injection of infliximab CT-P13 results in stable drug levels within 14-day treatment cycle in Crohn's disease. IFX drug levels are quite stable within 14-day treatment cycle, without trough levels in CD patients in remission during the maintenance therapy with CT-P13 sc. In patients with inactive CD under maintenance therapy with CT-P13 sc, therapeutic drug monitoring of IFX can be performed at any time between two CT-P13 sc injections. |
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
Prediction of Progression in Barrett's Esophagus Using a Tissue Systems Pathology Test: A Pooled Analysis of International Multicenter Studies. An objective tissue systems pathology test high risk class is a strong independent predictor of incident progression in BE patients. substantially improving progression risk prediction over clinical variables alone. While test specificity was high, sensitivity was modest. |
| Endoscopy |
Efficacy of endoscopic ligation with O-ring closure for preventing gastric post- ESD bleeding under antithrombotic therapy: A prospective observational study. E-LOC may be an effective option for closing mucosal defect after gastric ESD. However, the preventive effect on post-ESD bleeding should be further investigated in the high risk groups. |
Motorized Spiral Enteroscopy: Multicenter prospective study on performance and safety including in patients with surgically-altered gastrointestinal anatomy. MSE seems to be effective and safe endoscopic procedure. Total (pan-)enteroscopy can be achieved, in one or two sessions, even in the presence of surgically-altered GI anatomy. The total procedure time is relatively short. For both antegrade and retrograde MSE procedures, propofol sedation seems sufficient and safe. |
| Gastroenterology |
Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results. Though primary endpoints were not met, a >10% absolute difference in clinical remission was demonstrated with higher adalimumab maintenance dosing. Higher dosing regimens were generally well tolerated and consistent with the known safety profile of adalimumab in UC. ClinicalTrials.gov number, NCT002209456. |
Mucin 5AC-mediated CD44/ITGB1 clustering mobilizes adipose-derived mesenchymal stem cells to modulate pancreatic cancer stromal heterogeneity. MUC5AC, secreted during PC progression, enriches in adipose and enhances the mobilization of AD-MSCs. Upon recruitment to pancreatic tumors, AD-MSCs proliferate and contribute towards stromal heterogeneity. |
Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment. Together, these data suggest that stromal HIF2 is an essential component of PDAC pathobiology and is a druggable therapeutic target that could relieve tumor microenvironment immunosuppression and enhance immune responses in this disease. |
Transitional anal cells mediate colonic re-epithelialization in colitis. Transitional anal cells represent unique reserve cells capable of rebuilding epithelial structures in the colon after colitis. Further study of these cells could reveal novel approaches to direct mucosal healing in inflammation and disease. |
| Gastrointest Endosc |
A Comparison of the Morphology and Histopathology of Large Non-Pedunculated Colorectal Polyps in the Rectum and Colon: Implications for Endoscopic Treatment. This study suggests that, compared to LNPCPs in the rest of the colon, rectal LNPCPs are more likely to be larger and contain more advanced pathology. These findings have implications for curative endoscopic resection techniques particularly where early cancer is present. |
Defining the Learning Curves of Colorectal Surgical Trainees in Colonoscopy using the ACE tool. CRS fellows reached competency in colonoscopy around 275 to 300 procedures of experience, a trajectory similar to previously reported data for GI fellows, suggesting there is little difference in the learning curves between these two groups. In addition, no trainee was deemed competent at the onset of training despite an average experience well over the 50 colonoscopies required during residency. |
Outcomes for ESD of Pathologically Staged T1b Esophageal Cancer: A Multi-Center Study. On univariate analysis, R1 resection had a higher risk of recurrent disease (HR 6.25 (1.29, 30.36), p-value 0.023) CONCLUSION: EUS staging of T1b of EC has poor accuracy and staging ESD should be considered in these patients. ESD R0 resection rates are low in T1b EC, and R1 resection is associated with recurrent disease. Patients with non-curative ESD resection of T1b who cannot undergo surgery should be surveyed closely, as recurrent disease was seen in 25% of these patients. |
Polyps seen but not removed during index colonoscopy- an underestimated inefficiency in endoscopy practice. This study demonstrates that a small but significant proportion of small colorectal polyps are not removed at the time of diagnosis. This practice has implications for both patients and service provision. |
| Gut |
Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis. This study demonstrates that SQLE mediates oncogenesis via cell intrinsic effects and modulation of gut microbiota-metabolite axis. SQLE represents a therapeutic target and prognostic marker in CRC. |
| Hepatology |
Dedifferentiation-associated inflammatory factors of long-term expanded human hepatocytes exacerbate their elimination by macrophages during liver engraftment. These results revealed that lc-ProliHH triggers exacerbated macrophage activation by DAIF and provided potential solutions for clinical transplantation of lc-ProliHH. |
Dual roles of B lymphocytes in murine models of diet-induced non-alcoholic fatty liver disease. B lymphocytes have both detrimental and protective effects in HFD-induced NAFLD. The lack of secreted pathogenic antibodies protects partially from NAFLD, whereas the presence of certain B cell subsets provides additional protection. Interleukin 10-producing regulatory B cells may represent such a protective B cell subset. |
Metabolic subtypes of nonalcoholic fatty liver disease patients exhibit distinctive cardiovascular risk profiles. Metabolomic signatures identify three NAFLD subgroups, independent of histological disease severity. These signatures align with known CVD and genetic risk factors with subtype A exhibiting a lower CVD risk profile. This may account for the variation in hepatic vs cardiovascular outcomes, offering novel, clinically relevant, risk stratification. |
Risk Factors for Hepatocellular Cancer in Contemporary Cohorts of Patients with Cirrhosis. HCC incidence among patients with cirrhosis was lower than previously reported. HCC risk was variable across etiologies, with higher risk in patients with HCV cirrhosis and lower in those with NAFLD cirrhosis. Current smoking and overweight/obesity increased HCC risk across etiologies. |
| J Crohns Colitis |
How to manage inflammatory bowel disease patients when they withdraw anti-TNF due to severe anti-TNF-induced skin lesions? A multicenter cohort study. Early switch to a new biological is associated with higher probability of healing of anti-TNF-induced skin lesions and significantly reduces risk of IBD relapse. |
Prematurity, delivery method and infant feeding type are not associated with paediatric-onset inflammatory bowel disease risk: A Scottish retrospective birth cohort study. This population-based study demonstrates no association between mode of delivery, gestational age, or exclusive formula feeding at 6 weeks and the development of PIBD. |
| J Hepatol |
Acute Kidney Disease is Common and Associated with Poor Outcomes in Patients with Cirrhosis and Acute Kidney Injury. AKD develops in 1 in 3 hospitalized patients with cirrhosis and AKI and it is associated with worse survival and de-novo-CKD. Interventions that target AKD may improve outcomes of patients with cirrhosis and AKI. |
Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma. Our findings revealed the novel role of Ephrin-A3/EphA2 axis as a hypoxia-sensitive modulator of HCC cell metabolism and a key contributor of HCC initiation and progression. |
Multi-parametric analysis of human livers reveals variation in intrahepatic inflammation across phases of chronic hepatitis B infection. Our comprehensive multi-parametric analysis of human livers revealed distinct inflammatory profiles and pronounced differences in intrahepatic gene profiles across al chronic HBV phases in comparison to healthy liver. |
PKCa/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma. We propose that PKCa/ZFP64/CSF1 axis is critical for triggering immune evasion and anti-PD1 tolerance, and that inhibiting this axis with Gö6976 or lenvatinib overcame anti-PD1 resistance in HCC. |
Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models. aberrant protein NEDDylation contributes to cholangiocarcinogenesis by promoting cell survival and proliferation. Moreover, NEDDylation impacts the CCA-stroma crosstalk. Inhibition of NEDDylation with pevonedistat may represent a potential therapeutic strategy for patients with CCA. |
| J Neurogastroenterol Motil |
A Randomized, Double-Blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of DA-9701 (Motilitone) in Patients With Functional Dyspepsia and Constipation-type Irritable Bowel Syndrome Overlap: A Pilot Study. DA-9701 showed trend of treatment efficacy in patients with FD and IBS-C overlap including overall improvement, and safety, compared to placebo but without significance probably due to small numbers. It is suggested the need for a large-scale clinical trial to confirm this preliminary effect of DA-9701. |
| Neurogastroenterol Motil |
Association between post-reflux swallow-induced peristaltic wave index and esophageal mucosal integrity in patients with GERD symptoms. Esophageal chemical clearance is a major defense mechanism against reflux and its impairment represents a major determinant of reflux-associated mucosal damage. |
Retrospective evaluation of operator bias in the performance of high-resolution anorectal manometry. Operators obtain significantly different results during HRM despite using similar instructions to patients. Substantial differences in the proportion of patients with manometry findings suggestive of a defecatory disorder among operators may have a significant impact on the diagnoses and therapies offered to constipated patients. |
The symptom burden of Irritable Bowel Syndrome in tertiary care during the COVID-19 pandemic. This study has shown for the first time that patients seen in tertiary care with refractory IBS during the COVID-19 pandemic had a significantly higher symptom burden emphasizing the importance of gut-brain axis in IBS. Furthermore, lack of support and perceived loss of control appear to be contributory factors. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
Review article: current and emerging therapies for the management of cirrhosis and its complications. The improvement of clinical and patient-reported outcomes for patients with cirrhosis is possible by applying evidence-based pharmacotherapeutic approaches to the prevention and treatment of cirrhosis complications. |
Review article: Therapeutic targets for the pharmacologic management of coeliac disease-The future beyond a gluten-free diet. There is a need for pharmacologic options for CeD, either used adjunctively with a GFD for accidental or intentional gluten exposures or for refractory disease. Multiple promising agents are in development, and these trials are likely to lead to approvals for the first generation of pharmacologic agents for CeD within the next 5 years. |
| Gastroenterology |
Esophageal Motility Disorders: Current Approach to Diagnostics and Therapeutics. Since that time, significant advances have been made over the last 3 decades in our understanding of various esophageal motility disorders due to improvement in diagnostics with high resolution esophageal manometry (HRM). HRM has improved the sensitivity for detecting achalasia and has also enhanced our understanding of spastic and hypomotility disorders of the esophageal body. In this review, we discuss the current approach to diagnosis and therapeutics of various esophageal motility disorders. |
| Hepatology |
Biology of IDH Mutant Cholangiocarcinoma. This review will discuss the biology of mIDH iCCA, including roles of mIDH in blocking cell differentiation programs and suppressing anti-tumor immunity, and the potential relevance of these effects to mIDH1 targeted therapy. We also cover opportunities for synthetic lethal therapeutic interactions that harness the altered cell state provoked by mIDH1, rather than inhibiting the mutant enzyme. Finally, we highlight key outstanding questions in the biology of this fascinating and incompletely understood oncogene. |
Cholestatic Liver Diseases of Genetic Etiology: Advances and Controversies. Relevant to the current era, there are still gaps in knowledge of causation and pathogenesis, and lack of fully accepted biomarkers of disease progression and pruritus. We discuss strategies to overcome the challenges of genotype-phenotype correlation and draw the attention to the extrahepatic manifestations of these diseases. Finally, with attention to identifying causes and treatments of genetic cholestatic disorders, we anticipate a vibrant future of this dynamic field which builds upon current and future therapies, real-world evaluations of individual and combined therapeutics, and on the potential incorporation of effective gene editing and gene additive technologies. |
Diabetes Medications and Risk of Hepatocellular Carcinoma. From an endocrinology perspective, the main goal of treatment is the achievement of euglycemia; however, in patients at risk of, or with known underlying liver disease, the choice of diabetic medication as it relates to potential hepatic carcinogenesis remains complex and should be carefully considered. In the last decade, increasing evidence has suggested that metformin may reduce the risk of hepatocellular carcinoma, whereas evidence for other classes of diabetic medications, particularly some of the newer agents including the sodium glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists is fewer and often inconsistent. In this review, we aim to summarize the current evidence on the potential effects of the most widely used diabetic agents on liver cancer tumorigenesis. |
| Neurogastroenterol Motil |
Review of the indications, methods, and clinical utility of anorectal manometry and the rectal balloon expulsion test. The rectal balloon expulsion test is a useful, low-cost, radiation-free, outpatient assessment tool for impaired evacuation that is performed and interpreted in conjunction with ARM. The anorectal function tests should be interpreted with reference to age- and sex-matched normal values, clinical features, and results of other tests. A larger database of technique-specific normal values and newer paradigms of analyzing anorectal pressure profiles will increase the precision and diagnostic utility of HR-ARM for identifying abnormal mechanisms of defecation and continence. |
Letters to the editors and authors’ replies
| Clin Gastroenterol Hepatol |
| Hepatology |
| J Hepatol |
all remaining publications eg case reports, images of the month, etc…
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Inflamm Bowel Dis |